TREZEN – Perindopril is used for:
Treating high blood pressure. It may be used alone or along with other medicines. It is also used to reduce the risk of heart attack or death caused by heart problems in patients with stable coronary artery disease. It may also be used to treat other conditions as determined by your doctor.
TREZEN – Perindopril is an angiotensin-converting enzyme (ACE) inhibitor. It works by relaxing blood vessels. This helps to lower blood pressure.
Do NOT use TREZEN – Perindopril if:
- you are allergic to any ingredient in TREZEN – Perindopril
- you are pregnant
- you have a history of angioedema (swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness), including angioedema caused by treatment with an ACE inhibitor (eg, lisinopril)
- you have severe kidney problems
- you are also taking aliskiren and you have diabetes or kidney problems
Contact your doctor or health care provider right away if any of these apply to you.
Before using TREZEN – Perindopril:
Some medical conditions may interact with TREZEN – Perindopril. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are able to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems (eg, heart failure), blood vessel problems (eg, brain or heart blood vessels), bone marrow problems, liver problems, diabetes, or kidney problems (eg, renal artery stenosis)
- if you have a history of a stroke or kidney transplant
- if you have an autoimmune disease (eg, lupus, scleroderma)
- if you are dehydrated or have low blood volume
- if you have high blood potassium levels, low blood sodium levels, or are on a low-salt (sodium) diet
- if you are on dialysis or are scheduled to have surgery or receive anesthesia
Some MEDICINES MAY INTERACT with TREZEN – Perindopril. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Cyclosporine, eplerenone, potassium-sparing diuretics (eg, spironolactone, triamterene), potassium supplements, or trimethoprim because the risk of high blood potassium levels may be increased
- Everolimus or sirolimus because the risk of angioedema may be increased
- Aliskiren or angiotensin receptor blockers (eg, valsartan) because the risk of certain side effects (eg, kidney problems, high blood potassium levels, low blood pressure) may be increased
- Gold-containing medicines (eg, auranofin) because flushing, nausea, vomiting, and low blood pressure may occur
- Dextran sulfate or diuretics (eg, furosemide, hydrochlorothiazide) because they may increase the risk of TREZEN – Perindopril’s side effects
- Nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, celecoxib, ibuprofen, indomethacin) because they may increase the risk of kidney problems and decrease TREZEN – Perindopril’s effectiveness
- Lithium or sulfonylureas (eg, glyburide) because the risk of their side effects may be increased by TREZEN – Perindopril
This may not be a complete list of all interactions that may occur. Ask your health care provider if TREZEN – Perindopril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.